Protocol: does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)
Identifieur interne : 004529 ( Main/Exploration ); précédent : 004528; suivant : 004530Protocol: does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)
Auteurs : Nishat Siddiqi [Royaume-Uni] ; Margaret Bruce [Royaume-Uni] ; Christopher J. Neil [Royaume-Uni] ; Baljit Jagpal [Royaume-Uni] ; Graeme Maclennon [Royaume-Uni] ; Seonaidh C. Cotton [Royaume-Uni] ; Sofia A. Papadopoulo [Royaume-Uni] ; Nicholas Bunce [Royaume-Uni] ; Pitt Lim [Royaume-Uni] ; Konstantin Schwarz [Royaume-Uni] ; Satnam Singh [Royaume-Uni] ; David Hildick-Smith [Royaume-Uni] ; John D. Horowitz [Australie] ; Melanie Madhani [Royaume-Uni] ; Nicholas Boon [Royaume-Uni] ; Juan-Carlos Kaski [Royaume-Uni] ; Dana Dawson [Royaume-Uni] ; Michael P. Frenneaux [Royaume-Uni]Source :
- Journal of Translational Medicine [ 1479-5876 ] ; 2013.
Abstract
Whilst advances in reperfusion therapies have reduced early mortality from acute myocardial infarction, heart failure remains a common complication, and may develop very early or long after the acute event. Reperfusion itself leads to further tissue damage, a process described as ischaemia-reperfusion-injury (IRI), which contributes up to 50% of the final infarct size. In experimental models nitrite administration potently protects against IRI in several organs, including the heart. In the current study we investigate whether intravenous sodium nitrite administration immediately prior to percutaneous coronary intervention (PCI) in patients with acute ST segment elevation myocardial infarction will reduce myocardial infarct size. This is a phase II, randomised, placebo-controlled, double-blinded and multicentre trial.
The aim of this trial is to determine whether a 5 minute systemic injection of sodium nitrite, administered immediately before opening of the infarct related artery, results in significant reduction of IRI in patients with first acute ST elevation myocardial infarction (MI). The primary clinical end point is the difference in infarct size between sodium nitrite and placebo groups measured using cardiovascular magnetic resonance imaging (CMR) performed at 6–8 days following the AMI and corrected for area at risk (AAR) using the endocardial surface area technique. Secondary end points include (i) plasma creatine kinase and Troponin I measured in blood samples taken pre-injection of the study medication and over the following 72 hours; (ii) infarct size at six months; (iii) Infarct size corrected for AAR measured at 6–8 days using T2 weighted triple inversion recovery (T2-W SPAIR or STIR) CMR imaging; (iv) Left ventricular (LV) ejection fraction measured by CMR at 6–8 days and six months following injection of the study medication; and (v) LV end systolic volume index at 6–8 days and six months.
This study is funded by a grant from the UK Medical Research Council. This protocol is approved by the Scotland A Research Ethics Committee and has also received clinical trial authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) (EudraCT number: 2010-023571-26).
ClinicalTrials.gov:
Url:
DOI: 10.1186/1479-5876-11-116
PubMed: 23648219
PubMed Central: 3659075
Affiliations:
- Australie, Royaume-Uni
- Angleterre, Midlands de l'Ouest, Écosse
- Birmingham, Édimbourg
- Université d'Édimbourg, Université de Birmingham
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Nitrites in acute myocardial infarction (NIAMI)</title><author><name sortKey="Siddiqi, Nishat" sort="Siddiqi, Nishat" uniqKey="Siddiqi N" first="Nishat" last="Siddiqi">Nishat Siddiqi</name><affiliation wicri:level="1"><nlm:aff id="I1">Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD</wicri:regionArea><wicri:noRegion>Aberdeen AB25 2ZD</wicri:noRegion></affiliation></author><author><name sortKey="Bruce, Margaret" sort="Bruce, Margaret" uniqKey="Bruce M" first="Margaret" last="Bruce">Margaret Bruce</name><affiliation wicri:level="1"><nlm:aff id="I1">Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD</wicri:regionArea><wicri:noRegion>Aberdeen AB25 2ZD</wicri:noRegion></affiliation></author><author><name sortKey="Neil, Christopher J" sort="Neil, Christopher J" uniqKey="Neil C" first="Christopher J" last="Neil">Christopher J. Neil</name><affiliation wicri:level="1"><nlm:aff id="I1">Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD</wicri:regionArea><wicri:noRegion>Aberdeen AB25 2ZD</wicri:noRegion></affiliation></author><author><name sortKey="Jagpal, Baljit" sort="Jagpal, Baljit" uniqKey="Jagpal B" first="Baljit" last="Jagpal">Baljit Jagpal</name><affiliation wicri:level="1"><nlm:aff id="I1">Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD</wicri:regionArea><wicri:noRegion>Aberdeen AB25 2ZD</wicri:noRegion></affiliation></author><author><name sortKey="Maclennon, Graeme" sort="Maclennon, Graeme" uniqKey="Maclennon G" first="Graeme" last="Maclennon">Graeme Maclennon</name><affiliation wicri:level="1"><nlm:aff id="I2">Centre for Healthcare Randomised Trials (CHaRT) Health Services Research Unit, University of Aberdeen, Health Sciences Building, Foresterhill, Aberdeen AB25 2ZD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Healthcare Randomised Trials (CHaRT) Health Services Research Unit, University of Aberdeen, Health Sciences Building, Foresterhill, Aberdeen AB25 2ZD</wicri:regionArea><wicri:noRegion>Aberdeen AB25 2ZD</wicri:noRegion></affiliation></author><author><name sortKey="Cotton, Seonaidh C" sort="Cotton, Seonaidh C" uniqKey="Cotton S" first="Seonaidh C" last="Cotton">Seonaidh C. Cotton</name><affiliation wicri:level="1"><nlm:aff id="I2">Centre for Healthcare Randomised Trials (CHaRT) Health Services Research Unit, University of Aberdeen, Health Sciences Building, Foresterhill, Aberdeen AB25 2ZD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Healthcare Randomised Trials (CHaRT) Health Services Research Unit, University of Aberdeen, Health Sciences Building, Foresterhill, Aberdeen AB25 2ZD</wicri:regionArea><wicri:noRegion>Aberdeen AB25 2ZD</wicri:noRegion></affiliation></author><author><name sortKey="Papadopoulo, Sofia A" sort="Papadopoulo, Sofia A" uniqKey="Papadopoulo S" first="Sofia A" last="Papadopoulo">Sofia A. Papadopoulo</name><affiliation wicri:level="1"><nlm:aff id="I3">Cardiovascular Sciences Research Centre, Cranmer Terrace, London SW17 0RE, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiovascular Sciences Research Centre, Cranmer Terrace, London SW17 0RE</wicri:regionArea><wicri:noRegion>London SW17 0RE</wicri:noRegion></affiliation></author><author><name sortKey="Bunce, Nicholas" sort="Bunce, Nicholas" uniqKey="Bunce N" first="Nicholas" last="Bunce">Nicholas Bunce</name><affiliation wicri:level="1"><nlm:aff id="I4">Cardiology Department Atkinson Morley Wing, St Georges Healthcare NHS Trust, Blackshaw Road, London SW17 0Q, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiology Department Atkinson Morley Wing, St Georges Healthcare NHS Trust, Blackshaw Road, London SW17 0Q</wicri:regionArea><wicri:noRegion>London SW17 0Q</wicri:noRegion></affiliation></author><author><name sortKey="Lim, Pitt" sort="Lim, Pitt" uniqKey="Lim P" first="Pitt" last="Lim">Pitt Lim</name><affiliation wicri:level="1"><nlm:aff id="I4">Cardiology Department Atkinson Morley Wing, St Georges Healthcare NHS Trust, Blackshaw Road, London SW17 0Q, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiology Department Atkinson Morley Wing, St Georges Healthcare NHS Trust, Blackshaw Road, London SW17 0Q</wicri:regionArea><wicri:noRegion>London SW17 0Q</wicri:noRegion></affiliation></author><author><name sortKey="Schwarz, Konstantin" sort="Schwarz, Konstantin" uniqKey="Schwarz K" first="Konstantin" last="Schwarz">Konstantin Schwarz</name><affiliation wicri:level="1"><nlm:aff id="I1">Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD</wicri:regionArea><wicri:noRegion>Aberdeen AB25 2ZD</wicri:noRegion></affiliation></author><author><name sortKey="Singh, Satnam" sort="Singh, Satnam" uniqKey="Singh S" first="Satnam" last="Singh">Satnam Singh</name><affiliation wicri:level="1"><nlm:aff id="I1">Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD</wicri:regionArea><wicri:noRegion>Aberdeen AB25 2ZD</wicri:noRegion></affiliation></author><author><name sortKey="Hildick Smith, David" sort="Hildick Smith, David" uniqKey="Hildick Smith D" first="David" last="Hildick-Smith">David Hildick-Smith</name><affiliation wicri:level="1"><nlm:aff id="I5">Brighton and Sussex University Hospitals, Cardiology Research Unit, 1 Abbey Road, Brighton BN2 1ES, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Brighton and Sussex University Hospitals, Cardiology Research Unit, 1 Abbey Road, Brighton BN2 1ES</wicri:regionArea><wicri:noRegion>Brighton BN2 1ES</wicri:noRegion></affiliation></author><author><name sortKey="Horowitz, John D" sort="Horowitz, John D" uniqKey="Horowitz J" first="John D" last="Horowitz">John D. Horowitz</name><affiliation wicri:level="1"><nlm:aff id="I6">Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, 28 Woodville Road, Woodville South SA 5011, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, 28 Woodville Road, Woodville South SA 5011</wicri:regionArea><wicri:noRegion>Woodville South SA 5011</wicri:noRegion></affiliation></author><author><name sortKey="Madhani, Melanie" sort="Madhani, Melanie" uniqKey="Madhani M" first="Melanie" last="Madhani">Melanie Madhani</name><affiliation wicri:level="4"><nlm:aff id="I7">Centre for Cardiovascular Sciences College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cardiovascular Sciences College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT</wicri:regionArea><orgName type="university">Université de Birmingham</orgName><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Boon, Nicholas" sort="Boon, Nicholas" uniqKey="Boon N" first="Nicholas" last="Boon">Nicholas Boon</name><affiliation wicri:level="4"><nlm:aff id="I8">Centre for Cardiovascular Science, The University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SU, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Cardiovascular Science, The University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SU</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Kaski, Juan Carlos" sort="Kaski, Juan Carlos" uniqKey="Kaski J" first="Juan-Carlos" last="Kaski">Juan-Carlos Kaski</name><affiliation wicri:level="1"><nlm:aff id="I3">Cardiovascular Sciences Research Centre, Cranmer Terrace, London SW17 0RE, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiovascular Sciences Research Centre, Cranmer Terrace, London SW17 0RE</wicri:regionArea><wicri:noRegion>London SW17 0RE</wicri:noRegion></affiliation></author><author><name sortKey="Dawson, Dana" sort="Dawson, Dana" uniqKey="Dawson D" first="Dana" last="Dawson">Dana Dawson</name><affiliation wicri:level="1"><nlm:aff id="I1">Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD</wicri:regionArea><wicri:noRegion>Aberdeen AB25 2ZD</wicri:noRegion></affiliation></author><author><name sortKey="Frenneaux, Michael P" sort="Frenneaux, Michael P" uniqKey="Frenneaux M" first="Michael P" last="Frenneaux">Michael P. Frenneaux</name><affiliation wicri:level="1"><nlm:aff id="I1">Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD</wicri:regionArea><wicri:noRegion>Aberdeen AB25 2ZD</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Translational Medicine</title><idno type="eISSN">1479-5876</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Whilst advances in reperfusion therapies have reduced early mortality from acute myocardial infarction, heart failure remains a common complication, and may develop very early or long after the acute event. Reperfusion itself leads to further tissue damage, a process described as ischaemia-reperfusion-injury (IRI), which contributes up to 50% of the final infarct size. In experimental models nitrite administration potently protects against IRI in several organs, including the heart. In the current study we investigate whether intravenous sodium nitrite administration immediately prior to percutaneous coronary intervention (PCI) in patients with acute ST segment elevation myocardial infarction will reduce myocardial infarct size. This is a phase II, randomised, placebo-controlled, double-blinded and multicentre trial.</p></sec><sec><title>Methods and outcomes</title><p>The aim of this trial is to determine whether a 5 minute systemic injection of sodium nitrite, administered immediately before opening of the infarct related artery, results in significant reduction of IRI in patients with first acute ST elevation myocardial infarction (MI). The primary clinical end point is the difference in infarct size between sodium nitrite and placebo groups measured using cardiovascular magnetic resonance imaging (CMR) performed at 6–8 days following the AMI and corrected for area at risk (AAR) using the endocardial surface area technique. Secondary end points include (i) plasma creatine kinase and Troponin I measured in blood samples taken pre-injection of the study medication and over the following 72 hours; (ii) infarct size at six months; (iii) Infarct size corrected for AAR measured at 6–8 days using T2 weighted triple inversion recovery (T2-W SPAIR or STIR) CMR imaging; (iv) Left ventricular (LV) ejection fraction measured by CMR at 6–8 days and six months following injection of the study medication; and (v) LV end systolic volume index at 6–8 days and six months.</p></sec><sec><title>Funding, ethics and regulatory approvals</title><p>This study is funded by a grant from the UK Medical Research Council. This protocol is approved by the Scotland A Research Ethics Committee and has also received clinical trial authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) (EudraCT number: 2010-023571-26).</p></sec><sec><title>Trial registration</title><p>ClinicalTrials.gov: <ext-link ext-link-type="uri" xlink:href="http://clinicaltrials.gov/ct2/show/NCT01388504">NCT01388504</ext-link> and Current Controlled Trials: <ext-link ext-link-type="uri" xlink:href="http://www.controlled-trials.com/ISRCTN57596739/ISRCTN57596739">ISRCTN57596739</ext-link></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Keeley, Ec" uniqKey="Keeley E">EC Keeley</name></author><author><name sortKey="Boura, Ja" uniqKey="Boura J">JA Boura</name></author><author><name sortKey="Grines, Cl" uniqKey="Grines C">CL Grines</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krumholz, Hm" uniqKey="Krumholz H">HM Krumholz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yellon, Dm" uniqKey="Yellon D">DM Yellon</name></author><author><name sortKey="Hausenloy, Dj" uniqKey="Hausenloy D">DJ Hausenloy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halestrap, Ap" uniqKey="Halestrap A">AP Halestrap</name></author><author><name sortKey="Clarke, Sj" uniqKey="Clarke S">SJ Clarke</name></author><author><name sortKey="Javadov, Sa" uniqKey="Javadov S">SA Javadov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halestrap, Ap" uniqKey="Halestrap A">AP Halestrap</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murry, Ce" uniqKey="Murry C">CE Murry</name></author><author><name sortKey="Jennings, Rb" uniqKey="Jennings R">RB Jennings</name></author><author><name sortKey="Reimer, Ka" uniqKey="Reimer K">KA Reimer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hausenloy, Dj" uniqKey="Hausenloy D">DJ Hausenloy</name></author><author><name sortKey="Yellon, Dm" uniqKey="Yellon D">DM Yellon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sumeray, Ms" uniqKey="Sumeray M">MS Sumeray</name></author><author><name sortKey="Yellon, Dm" uniqKey="Yellon D">DM Yellon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yellon, Dm" uniqKey="Yellon D">DM Yellon</name></author><author><name sortKey="Downey, Jm" uniqKey="Downey J">JM Downey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hausenloy, Dj" uniqKey="Hausenloy D">DJ Hausenloy</name></author><author><name sortKey="Yellon, Dm" uniqKey="Yellon D">DM Yellon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kharbanda, Rk" uniqKey="Kharbanda R">RK Kharbanda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsang, A" uniqKey="Tsang A">A Tsang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miura, T" uniqKey="Miura T">T Miura</name></author><author><name sortKey="Miki, T" uniqKey="Miki T">T Miki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Botker, He" uniqKey="Botker H">HE Botker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hackett, D" uniqKey="Hackett D">D Hackett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Piot, C" uniqKey="Piot C">C Piot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lundberg, Jo" uniqKey="Lundberg J">JO Lundberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furchgott, Rf" uniqKey="Furchgott R">RF Furchgott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kollau, A" uniqKey="Kollau A">A Kollau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Basu, S" uniqKey="Basu S">S Basu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gladwin, Mt" uniqKey="Gladwin M">MT Gladwin</name></author><author><name sortKey="Kim Shapiro, Db" uniqKey="Kim Shapiro D">DB Kim-Shapiro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webb, Aj" uniqKey="Webb A">AJ Webb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maher, Ar" uniqKey="Maher A">AR Maher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calvert, Jw" uniqKey="Calvert J">JW Calvert</name></author><author><name sortKey="Lefer, Dj" uniqKey="Lefer D">DJ Lefer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hendgen Cotta, Ub" uniqKey="Hendgen Cotta U">UB Hendgen-Cotta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webb, A" uniqKey="Webb A">A Webb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dezfulian, C" uniqKey="Dezfulian C">C Dezfulian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gonzalez, Fm" uniqKey="Gonzalez F">FM Gonzalez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baskin, Si" uniqKey="Baskin S">SI Baskin</name></author><author><name sortKey="Horowitz, Am" uniqKey="Horowitz A">AM Horowitz</name></author><author><name sortKey="Nealley, Ew" uniqKey="Nealley E">EW Nealley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yawata, Y" uniqKey="Yawata Y">Y Yawata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rehman, Hu" uniqKey="Rehman H">HU Rehman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dezfulian, C" uniqKey="Dezfulian C">C Dezfulian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Regan, Dp" uniqKey="O Regan D">DP O'Regan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schulz Menger, J" uniqKey="Schulz Menger J">J Schulz-Menger</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Midlands de l'Ouest</li><li>Écosse</li></region><settlement><li>Birmingham</li><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li><li>Université de Birmingham</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Siddiqi, Nishat" sort="Siddiqi, Nishat" uniqKey="Siddiqi N" first="Nishat" last="Siddiqi">Nishat Siddiqi</name></noRegion><name sortKey="Boon, Nicholas" sort="Boon, Nicholas" uniqKey="Boon N" first="Nicholas" last="Boon">Nicholas Boon</name><name sortKey="Bruce, Margaret" sort="Bruce, Margaret" uniqKey="Bruce M" first="Margaret" last="Bruce">Margaret Bruce</name><name sortKey="Bunce, Nicholas" sort="Bunce, Nicholas" uniqKey="Bunce N" first="Nicholas" last="Bunce">Nicholas Bunce</name><name sortKey="Cotton, Seonaidh C" sort="Cotton, Seonaidh C" uniqKey="Cotton S" first="Seonaidh C" last="Cotton">Seonaidh C. Cotton</name><name sortKey="Dawson, Dana" sort="Dawson, Dana" uniqKey="Dawson D" first="Dana" last="Dawson">Dana Dawson</name><name sortKey="Frenneaux, Michael P" sort="Frenneaux, Michael P" uniqKey="Frenneaux M" first="Michael P" last="Frenneaux">Michael P. Frenneaux</name><name sortKey="Hildick Smith, David" sort="Hildick Smith, David" uniqKey="Hildick Smith D" first="David" last="Hildick-Smith">David Hildick-Smith</name><name sortKey="Jagpal, Baljit" sort="Jagpal, Baljit" uniqKey="Jagpal B" first="Baljit" last="Jagpal">Baljit Jagpal</name><name sortKey="Kaski, Juan Carlos" sort="Kaski, Juan Carlos" uniqKey="Kaski J" first="Juan-Carlos" last="Kaski">Juan-Carlos Kaski</name><name sortKey="Lim, Pitt" sort="Lim, Pitt" uniqKey="Lim P" first="Pitt" last="Lim">Pitt Lim</name><name sortKey="Maclennon, Graeme" sort="Maclennon, Graeme" uniqKey="Maclennon G" first="Graeme" last="Maclennon">Graeme Maclennon</name><name sortKey="Madhani, Melanie" sort="Madhani, Melanie" uniqKey="Madhani M" first="Melanie" last="Madhani">Melanie Madhani</name><name sortKey="Neil, Christopher J" sort="Neil, Christopher J" uniqKey="Neil C" first="Christopher J" last="Neil">Christopher J. Neil</name><name sortKey="Papadopoulo, Sofia A" sort="Papadopoulo, Sofia A" uniqKey="Papadopoulo S" first="Sofia A" last="Papadopoulo">Sofia A. Papadopoulo</name><name sortKey="Schwarz, Konstantin" sort="Schwarz, Konstantin" uniqKey="Schwarz K" first="Konstantin" last="Schwarz">Konstantin Schwarz</name><name sortKey="Singh, Satnam" sort="Singh, Satnam" uniqKey="Singh S" first="Satnam" last="Singh">Satnam Singh</name></country><country name="Australie"><noRegion><name sortKey="Horowitz, John D" sort="Horowitz, John D" uniqKey="Horowitz J" first="John D" last="Horowitz">John D. Horowitz</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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